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Xavier Brazzolotto Selected Research

Cholinergic Agents (Cholinergics)

11/2018The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.
1/2017N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
12/2016Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

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Xavier Brazzolotto Research Topics

Disease

14Alzheimer Disease (Alzheimer's Disease)
04/2023 - 08/2015
3Neurodegenerative Diseases (Neurodegenerative Disease)
05/2023 - 08/2015
1Poisoning
05/2024
1Parkinson Disease (Parkinson's Disease)
05/2023
1Neuroblastoma
02/2021
1Mitochondrial Diseases (Mitochondrial Disease)
02/2021
1Apnea
01/2021
1Status Epilepticus (Complex Partial Status Epilepticus)
01/2021
1Amnesia (Dissociative Amnesia)
04/2019
1Dementia (Dementias)
11/2018
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
02/2003
1Myeloid Leukemia (Leukemia, Myelocytic)
02/2003
1Neoplasms (Cancer)
02/2003

Drug/Important Bio-Agent (IBA)

11ButyrylcholinesteraseIBA
05/2023 - 01/2017
4LigandsIBA
05/2023 - 08/2018
3Cholinergic Agents (Cholinergics)IBA
11/2018 - 12/2016
2EnzymesIBA
05/2024 - 04/2023
2Monoamine Oxidase (MAO)IBA
02/2021 - 01/2017
2AntioxidantsIBA
02/2021 - 08/2018
2Cholinesterase Inhibitors (Anticholinesterases)IBA
01/2021 - 12/2020
2Tryptophan (L-Tryptophan)FDA Link
04/2019 - 03/2019
2Scopolamine (Hyoscine)FDA Link
04/2019 - 11/2018
1Aryldialkylphosphatase (Paraoxonase)IBA
05/2024
1AntidotesIBA
05/2024
1Nerve AgentsIBA
05/2024
1Free Radical ScavengersIBA
05/2023
1Chelating AgentsIBA
05/2023
1Cholinesterases (Cholinesterase)IBA
05/2023
12-(N-cyclohexylamino)ethanesulfonic acid (CHES)IBA
05/2023
1AcetylcholinesteraseIBA
05/2023
1Oxidoreductases (Dehydrogenase)IBA
05/2023
1Trace Elements (Biometals)IBA
05/2023
1Oxidopamine (6 Hydroxydopamine)IBA
05/2023
1CatecholsIBA
02/2021
1Neurotransmitter Agents (Neurotransmitter)IBA
02/2021
1Isoflurophate (DFP)FDA Link
01/2021
1Succinylcholine (Suxamethonium Chloride)FDA LinkGeneric
01/2021
1Mivacurium (Mivacron)FDA Link
01/2021
1Tacrine (Cognex)FDA Link
04/2019
1Doxorubicin (Adriamycin)FDA LinkGeneric
02/2003
1IronIBA
02/2003
1RNA (Ribonucleic Acid)IBA
02/2003
1AnthracyclinesIBA
02/2003
1Iron-Regulatory Proteins (Iron-Responsive Element Binding Proteins)IBA
02/2003
1glucose tetrasaccharideIBA
02/2003

Therapy/Procedure

3Therapeutics
05/2023 - 08/2015